Many patients have non- specific pain in both joints and muscles, have tried anti- inflammatories that work for a bit and then stop, and yet, according to their doctor, are showing no signs of arthritic changes.
The body is a web and symptoms are never in isolation. What else may be happening that will help to diagnose the cause of the chronic inflammation? Interestingly, in the extraction and investigation of the cause, there are 2 possibilities that may contribute to Chronic Inflammation.
1. Kryptopyrroles (what????)
2. Vitamin B6 deficiency
Pyrroles are normal by- products of hemoglobin synthesis. Pyrrole disorder is a genetic (but fairly common) over- production of Pyrrole molecules. Pyrroles, in themselves, have no function in the body but they love zinc and B6 and bind to these substrates, pulling them out the body when the pyrroles are excreted. The result of this is a functional deficiency in both zinc and vit B6. Why is this important? Because the depletion of both zinc and vit B6 manifests in some unpleasant signs and symptoms, one of which is Chronic Inflammation.
What are the signs and symptoms of Vit B6 Deficiency?
A vitamin B6 deficiency can, over time, cause symptoms including:
- Changes in mood, such as irritability, anxiety and depression
- Muscle pains
- Worsening of PMS symptoms
- Symptoms of anemia which may also be associated with iron deficiency or vitB12 deficiency.
In a study published in the Journal of Nutrition, researchers compared blood levels of vitamin B6 and 13 different indicators of inflammation in 2,229 adults enrolled in the Framingham Offspring study.
Although previous studies have linked low blood levels of vitamin B6 with various signs of inflammation, such as C-reactive protein (CRP), researchers say this is the first large-scale study to look at the relationship between the vitamin and a variety of inflammation indicators.
The results showed that people with the highest overall inflammation score based on the 13 different indicators had the lowest blood levels of vitamin B6.
The reverse was also true. Those who had the highest blood levels of vitamin B6 had the lowest levels of chronic inflammation.
What about a zinc deficiency?
- Skin, nails and hair. Zinc deficiency may manifest as acne, eczema, xerosis (dry, scaling skin), seborrheic dermatitis, or alopecia (thin and sparse hair).
- White spots on nails
- Mouth ulcers
- Diminished Vision, smell and taste. …
- Compromised Immune system.
- Poor Appetite.
- Poor Cognitive function
- Psychological disorders.
If you have mood disorders, alcoholism, OCD or are bipolar, there is a possibility you have problems with pyrroles. However, signs and symptoms of B6 or zinc deficiency may not mean you have pyrroles in the urine but it is a good idea to check out any low nutrient status .
Both Pyrolurea and nutrient deficiencies are easily corrected.
___ ___ Do you sunburn easily? Do you have fair or pale skin?
___ ___ Do you react poorly to stress and avoid stressful situations?
___ ___ Do you have poor dream recall or only nightmares?
___ ___ Is it hard to recall what you’ve just read?
___ ___ Are your eyes sensitive to bright lights?
___ ___ Do you get frequent colds or infections?
___ ___ Are there white spots on your fingernails?
___ ___ Are you prone to acne, dermatitis, eczema, or psoriasis?
___ ___ Do you have stretch marks on your abdomen or thighs?
___ ___ Do you prefer not to eat breakfast or even experience light
___ ___ Are there severe mood problems, ADHD, mental illness, or
___ ___ Is your hair thin and sparse or do you have prematurely grey
___ ___ Have you been described as anti- social?
___ ___ Do you frequently feel anxious or unreasonably fearful?
___ ___ Do you have frequent headaches?
___ ___ Do loud noises bother you? May also relate to a magnesium deficiency.
___ ___ Have you noticed a sweet fruity smell to your breath or sweat when ill or stressed?
___ ___ Do you have a poor appetite or a poor sense of taste?
___ ___ Do you have any upper abdominal pain? Do you easily get a stitch when running?
___ ___ Do your knees creak when bending or ache?
___ ___ Does criticism offend you?
___ ___ Do you have frequent mood swings and/or severe PMS?
___ ___ Do you tend to carry excess fat in your lower extremities (a pear-shaped figure)?
If you answered yes to more than 8 of the symptoms, it is worth investigating further. In this day and age, the possibility of simply being nutrient deficient, rather than having Kryptopyrrolia, is very possible but the impact of untreated nutrient deficiency grows as we age and some small changes to diet, as well as adding carefully chosen supplements is very do-able.